Full Time Cell Optimization
• For Maximal Phenotypic and Genotypic Integrity of Cells
• For Minimal Cell Population Variability
CELLS OUTSIDE THE BODY
Exist in 4 places as metabolizing cells.
INCUBATION
• C02 Incubator
• 02/C02 Incubator
• Thermal Incubator
• Bioreactor
• etc.
HANDLING
• BSL2 Hood
• Laminar Clean Hood
• Glove Box
• Lab Bench
• etc.
MACHINES
• Microscope
• Sorter
• Separator
• Reader
• Centrifuge
• Mixer
• Analyzer
• Robot
• etc.
TRANSPORT
• Incubator to Hood
• Hood to Incubator
• Hood to Machine
• Machine to Incubator
• etc.
Quality recognizes that for best cell potency and maximal cell integrity, cells need full-time optimization of all critical cell process parameters O2/ROS, CO2/pH, RH/osmolarity, and temperature. Full time is best process control possible and means not just part-time during incubation in bioreactors or incubators, but also during handling, machine processing, and transport. The Xvivo System model X2 Platform does this now.
CELLS OUTSIDE THE BODY
INCUBATION
• C02 Incubator
• 02/C02 Incubator
• Thermal Incubator
• Bioreactor
• etc.

HANDLING
• BSL2 Hood
• Laminar Clean Hood
• Glove Box
• Lab Bench
• etc.
MACHINES
• Microscope
• Sorter
• Separator
• Reader
• Centrifuge
• Mixer
• Analyzer
• Robot
• etc.
TRANSPORT
• Incubator to Hood
• Hood to Incubator
• Hood to Machine
• Machine to Incubator
• etc.
CONVENTIONAL INCUBATORS
(open into room)
CYTOCENTRIC INCUBATORS
Xvivo System
CELLS OUTSIDE THE BODY
INCUBATION
• C02 Incubator
• 02/C02 Incubator
• Thermal Incubator
• Bioreactor
• etc.
HANDLING
• BSL2 Hood
• Laminar Clean Hood
• Glove Box
• Lab Bench
• etc.

MACHINES
• Microscope
• Sorter
• Separator
• Reader
• Centrifuge
• Mixer
• Analyzer
• Robot
• etc.
TRANSPORT
• Incubator to Hood
• Hood to Incubator
• Hood to Machine
• Machine to Incubator
• etc.
CONVENTIONAL HOOD HANDLING
(BSL-2)
CYTOCENTRIC HANDLING
Xvivo System
Quality recognizes that all typical negative side-effects of machines on cells (particles, heat, vibration, etc.) must be neutralized to make all analytic, process, and automation equipment compatible with a cell optimized ecosystem. Machines must also operate aseptically and be protected themselves from dust, aerosols, and corrosion. The Xvivo GMP System® Platform does this now.
CELLS OUTSIDE THE BODY
INCUBATION
• C02 Incubator
• 02/C02 Incubator
• Thermal Incubator
• Bioreactor
• etc.
HANDLING
• BSL2 Hood
• Laminar Clean Hood
• Glove Box
• Lab Bench
• etc.
MACHINES
• Microscope
• Sorter
• Separator
• Reader
• Centrifuge
• Mixer
• Analyzer
• Robot
• etc.

TRANSPORT
• Incubator to Hood
• Hood to Incubator
• Hood to Machine
• Machine to Incubator
• etc.
CONVENTIONAL MACHINES
CYTOCENTRIC MACHINES
CELLS OUTSIDE THE BODY
INCUBATION
• C02 Incubator
• 02/C02 Incubator
• Thermal Incubator
• Bioreactor
• etc.
HANDLING
• BSL2 Hood
• Laminar Clean Hood
• Glove Box
• Lab Bench
• etc.
MACHINES
• Microscope
• Sorter
• Separator
• Reader
• Centrifuge
• Mixer
• Analyzer
• Robot
• etc.
TRANSPORT
• Incubator to Hood
• Hood to Incubator
• Hood to Machine
• Machine to Incubator
• etc.
